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Sugar- and artificially sweetened beverages and the risks of stroke and dementia

14 / 11 / 17

This study examined the hypothesis that sugar- or artificially sweetened beverage consumption is associated with the prospective risks of stroke or dementia in the Framingham Heart Offspring Cohort. It examined 2888 people aged over 45 for incident stroke and 1484 people over 60 years for incident dementia. Beverage intake was quantified via food frequency questionnaires, and incident events monitored over 10 years.

Over this time 97 cases of incident stroke were observed (82 ischaemic) and 81 incident cases of dementia. After adjustments for age, sex, education, caloric intake, diet quality, physical activity and smoking, higher recent and cumulative intake of artificially sweetened soft drinks were associated with an increased risk of ischaemic stroke, all-cause dementia, and Alzheimers dementia. When comparing daily cumulative intake to 0 per week (reference), the hazard ratios were 2.96 (95% confidence interval, 1.26-6.97) for ischemic stroke, and 2.89 (95% confidence interval, 1.18-7.07) for Alzheimer's disease. Sugar-sweetened beverages were not associated with stroke or dementia.


Pase MP. Himali JJ, Beiser AS et al. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke 2017; 48(5):1139-1146