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Sweetening yoghurt with glucose, but not with saccharin promotes weight gain and increased fat pad mass in rats

08 / 08 / 16

Boakes RA, Kendig MD, Martire SI et al. Sweetening yoghurt with glucose, but not with saccharin promotes weight gain and increased fat pad mass in rats. Appetite. 2016 May 14;105:114-128

This University of Sydney rat study aimed to repeat previously published experiments by Swithers & Davidson (2008) in which non-nutritive sweeteners unexpectedly accelerated weight gain.

This study compared weight gain in rats fed yoghurt with added glucose, saccharin or nothing (control) in addition to their usual chow. There was no difference in weight gain, fasting blood glucose or insulin measures between the saccharin and control groups, whereas the glucose group had the largest fat pads at the end of the study, and some impairment of glucose sensitivity. Contrary to Swithers & Davidson, saccharin had no effects on body weight.

These results show effects consistent with previous studies and demonstrate the weight gain potential of glucose when administered in excess of energy requirements in rats.