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Sickeningly sweet: does sugar cause chronic disease?

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In this commentary, John Sievenpiper suggests low quality ecologic studies, animal models of overfeeding at levels far beyond population intakes and select human interventions lacking control for energy have been used to implicate fructose containing sugars in obesity and diabetes. The theorised biochemical mechanisms for sugars causing metabolic disease remain questionable in their clinical translation. When he applies an evidence-based framework assessing the totality of the highest level of evidence from prospective cohort studies and controlled trials, a causal relationship between sugars and chronic disease is far from proven.

John L Sievenpiper. Sickeningly sweet: does sugar cause chronic disease? No. Can J Diabetes2016;40:287-295