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Research Updates | Obesity / Overweight

Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion - the DIETFITS Randomised Clinical Trial

16 / 04 / 18

Finding: Weight change was not significantly different in the healthy low-fat diet (HLF) vs the healthy low-carbohydrate diet (HLC) and there was no significant diet-genotype interaction or diet-insulin interaction.

Summary: The Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) randomised clinical trial included 609 adult men and women aged 18-50 years without diabetes and a BMI between 28-40. Subjects were randomised into either a HLF or HLC diet emphasising diet quality for 12 months, delivered by health educators in small groups. Each subject was also tested for 3 single nucleotide polymorphism multilocus responsiveness patterns and insulin secretion to determine if these were associated with weight loss.

Mean macronutrient distributions achieved over the 12 months were HLF (48% carb; 29% fat) vs HLC (30% carb; 45% fat). Weight change at 12 months was -5.3kg for HLF and -6kg for HLC. There was no significant diet-genotype pattern interaction or diet-insulin secretion interaction with weight loss.

Citation: Gardner CD, Trepanowski JF, Del Gobbo LC et al. Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion- the DIETFITS Randomised Clinical Trial. JAMA 2018;319(7):667-679