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Research Updates | Cardiovascular disease

Effect of fructose on established lipid targets: A systematic review and meta-analysis of controlled feeding trials

09 / 11 / 15

Wolever TM, Beyene J, Kendall CW, Jenkins DJ, Sievenpiper JL. J Am Heart Assoc. 2015 Sep 10;4(9). pii: e001700.

Study design: meta-analysis

There is much debate on the role of fructose in cardiovascular risk. This meta-analysis examined the effects of fructose on established lipid targets in 51 controlled isocaloric feeding trials in which fructose was substituted for other carbohydrates, and 8 hypercaloric trials in which fructose was provided in excess compared to controlled diets (21-35% energy).

Fructose had no effect on LDL cholesterol, non-HDL cholesterol, apolipoprotein B, triglycerides, or HDL cholesterol in isocaloric trials, whereas in hypercaloric trials fructose in excess increased apolipoprotein B in 2 trials, and increased triglycerides in 8 trials. The authors suggest this study is limited by small sample size, limited follow up and low quality of the included trials.